As well as his two Sunday services, and a week night lecture, Eadie also did a Sunday night sermon once a month. He also held Bible classes and visited the sick, conducted baptisms, weddings and funerals.

In 1849 a cholera epidemic broke out in the city, with many in his congregation succumbing to the disease, but still he would visit them while sick, and later spoke of the ‘dreadful nature’ of it.

Eadie remained at Cambridge Street until 1863.

On 3rd February Eadie married Allison Pringle Palfrey from Edinburgh but whom he had met in Alva as she had relatives there. The couple lived in a flat in Cambridge Street for 13 years where they had five children, although the two boys and one of the girls died. In 1854 they moved to a house in Lansdowne Crescent, eventually ending up in Thornville Terrace.

In May 1843 Eadie was elected to the chair of Biblical Literature in the Secession Hall and the following year the University of Glasgow conferred the degree of LLD on him. In 1850 he was made a Doctor of Divinity by the University of St Andrews.

On 4th August 1855, his wife died following a short illness. Eadie was inconsolable. He took furlough to the south of England and returned to work in January 1856, throwing himself back into it. The following year he was chosen as Moderator for his church.

Eadie was a prolific writer and submitted work to various publications including the North British Review. In 1840 he had become editor of the Voluntary Church Magazine and in 1857, a Glasgow publisher wanted to print a dictionary of biography and Eadie was charged with the ecclesiastical section, as both editor and contributor.

On 8th October 1862 Eadie married once more. She was Mary Home of Berwick-upon-Tweed and a year later he moved to the Lansdowne Church.

In January 1870, he embarked a trip to Egypt, Sinai, and Palestine. He, along with a party of other ministers, visited Cairo, the Pyramids and travelled down the Suez before spending time in the desert. They also visited Nazareth and Beirut coming back by Greece and Italy three months later. In 1873 Eadie visited the United States and Canada. By this time, he was ill. He had a heart complaint and as the years passed, the symptoms grew worse.

On Saturday 3rd June 1876 he died. His funeral on the 7th attracted many mourners who paid their last respects as he made his final journey to his resting place at the Glasgow Necropolis.